Hydrochloric Acid → HCID 178483104, compound

HRID 1170063Notes

Reaction equation

HRID 1170063 reaction equation
[CH3:1][N:2]([CH3:26])[C:3]1[C:8]([C:9]#[N:10])=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6]([C:17]#[N:18])=[C:5]([S:19]C2C=CC=CC=2)[N:4]=1.[S-2].[Na+].[Na+].Cl>CN(C)C=O>[CH3:1][N:2]([CH3:26])[C:3]1[C:8]([C:9]#[N:10])=[C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:6]([C:17]#[N:18])=[C:5]([SH:19])[N:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14804Sodium SulfideHCID 12018342HCID 12018342, compound

Product 1

HCID 178483104HCID 178483104, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

Under argon, 280 mg (0.79 mmol) of 2-dimethylamino-4-phenyl-6-phenylsulfanyl-3,5-pyridinedicarbonitrile (step 2) are dissolved in 3 ml of abs. dimethylformamide (DMF), and 204 mg (2.6 mmol) of sodium sulfide are added. The reaction mixture is stirred at 80° C. for 2 hours. 6 ml of 1 N hydrochloric acid are added to the mixture and the resulting yellow crystals are filtered off with suction, washed with water and petroleum ether/diethyl ether 1/1 and dried under reduced pressure overnight.

Workup

  1. filtrationthe resulting yellow crystals are filtered off with suction
  2. washwashed with water and petroleum ether/diethyl ether 1/1
  3. customdried under reduced pressure overnight

Sources & evidence

ORD record
ord-515af22bb940470391bbbe51bbec291b
Source dataset
uspto-grants-2010_11
Patent number
US07825255B2

Reaction notes

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