Piperidine → HCID 58654441, compound

HRID 1170522Notes

Reaction equation

HRID 1170522 reaction equation
C1C2C(COC([N:18]3[CH2:22][CH2:21][CH2:20][CH:19]3[C:23](=[O:38])[NH:24][CH2:25][C:26]3[CH:31]=[C:30]([CH3:32])[N:29]=[C:28]([N:33]4[CH:37]=[CH:36][N:35]=[CH:34]4)[N:27]=3)=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>CN(C)C=O>[N:33]1([C:28]2[N:27]=[C:26]([CH2:25][NH:24][C:23]([CH:19]3[CH2:20][CH2:21][CH2:22][NH:18]3)=[O:38])[CH:31]=[C:30]([CH3:32])[N:29]=2)[CH:37]=[CH:36][N:35]=[CH:34]1

Participants

4

Reactant 2

HCID 8082PiperidineHCID 58654332HCID 58654332, compound

Product 1

HCID 58654441HCID 58654441, compoundYield 99.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 2-[(2-imidazol-1-yl-6-methyl-pyrimidin-4-ylmethyl)-carbamoyl]-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester (435 mg, 0.855 mmol) in dimethylformamide (3.2 mL) was added piperidine (800 μL, 8.09 mmol) at r.t. The solution was stirred for 20 min then concentrated under vacuum to afford 244 mg of pyrrolidine-2-carboxylic acid (2-imidazol-1-yl-6-methyl-pyrimidin-4-ylmethyl)-amide as a brown oil. [M+H]+ 287.28.

Workup

  1. concentrationthen concentrated under vacuum

Sources & evidence

ORD record
ord-167fbed9430b4a278832e15ef7bf8013
Source dataset
uspto-grants-2010_11
Patent number
US07825256B2

Reaction notes

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