2-Bromoethanol → 4-Methoxybenzyl 4-(2-hydroxyethoxy)benzoate

HRID 1170645Notes

Reaction equation

HRID 1170645 reaction equation
[OH:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:27][CH2:28][OH:29]>CN(C)C=O>[OH:29][CH2:28][CH2:27][O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH2:9][C:10]2[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[CH:12][CH:11]=2)=[O:7])=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 108982-BromoethanolHCID 11430Potassium CarbonateHCID 12119266Benzoic acid, 4-hydroxy-, (4-methoxyphenyl)methyl ester

Product 1

HCID 220358874-Methoxybenzyl 4-(2-hydroxyethoxy)benzoate

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of 4-methoxybenzyl 4-hydroxybenzoate (7.0 g, 27 mmole) in dry N,N-dimethylformamide (50 ml) was added potassium carbonate (4.15 g, 30 mmole) and 2-bromoethanol. The mixture was stirred 48 hours at 80° C., evaporated under reduced pressure and ethyl acetate and water were added. The organic phase was washed five times with water and dried with sodium sulfate. The solution was evaporated under reduced pressure and the product was isolated by silica gel column chromatography with hexane/ethyl acetate.

Workup

  1. customevaporated under reduced pressure and ethyl acetate and water
  2. additionwere added
  3. washThe organic phase was washed five times with water
  4. dry with materialdried with sodium sulfate
  5. customThe solution was evaporated under reduced pressure
  6. customthe product was isolated by silica gel column chromatography with hexane/ethyl acetate

Sources & evidence

ORD record
ord-6ce506c1aa2749b59055dadf94fd9188
Source dataset
uspto-grants-2010_11
Patent number
US07825238B2

Reaction notes

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