Dimethylacetamide → 2-Methyl-4(3H)-quinazolinone

HRID 1171040Notes

Reaction equation

HRID 1171040 reaction equation
CN1C[C:6](=[O:8])[C:5]2[CH:9]=[CH:10][CH:11]=[CH:12][C:4]=2O1.C([O-])(=O)C.[NH4+:17].C[N:19](C)[C:20](=O)[CH3:21]>>[CH3:21][C:20]1[NH:17][C:6](=[O:8])[C:5]2[C:4](=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:19]=1

Participants

4

Reactant 3

HCID 31374DimethylacetamideHCID 517165Ammonium AcetateHCID 68679541HCID 68679541, compound

Product 1

HCID 1354004572-Methyl-4(3H)-quinazolinone

Procedure

2-Methylbenzoxazin-4-one (0.24 mole) and ammonium acetate (0.30 mole) is given in 50 ml of N,N-dimethylacetamide and then heated to 160° under a nitrogen blanket for 2 h. After cooling to rt, the white solid is collected by filtration and washed with diethyl ether. Air drying give 2-methyl-quinazolin-4-one.

Workup

  1. temperatureheated to 160° under a nitrogen blanket for 2 h
  2. filtrationthe white solid is collected by filtration
  3. washwashed with diethyl ether
  4. customAir drying

Sources & evidence

ORD record
ord-80c60db7c08e4cd6a3132bad404d67a3
Source dataset
uspto-grants-2010_11
Patent number
US07829566B2

Reaction notes

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