Citric Acid → (3-Amino-6-iodo-pyrazin-2-yl)-phenyl-methanone
Reaktionsgleichung
CON(C)[C:4]([C:6]1[C:11]([NH2:12])=[N:10][CH:9]=[C:8]([I:13])[N:7]=1)=[O:5].[C:15]1([Mg]Br)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.C(O)(=O)CC(CC(O)=O)(C(O)=O)O>C1COCC1.CCOCC.O.ClCCl>[NH2:12][C:11]1[C:6]([C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:5])=[N:7][C:8]([I:13])=[CH:9][N:10]=1Komponenten
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 4
Reaktionsbedingungen
- Temperatur
- 55 °C
Versuchsvorschrift
8.00 g (25.97 mmol) of 3-amino-6-iodo-pyrazine-2-carboxylic acid methoxy-methyl-amide was dissolved in 100 ml of anhydrous THF under nitrogen. The solution was cooled to 55° C. and 27 ml of a 3 M solution of phenylmagnesium bromide in ether was added. The mixture was allowed to warm to 10° C. and a solution of 10% citric acid in water was added. The mixture was diluted with dichloromethane and the phases were separated. The aqueous phase was extracted three times with dichloromethane and the combined organic phases were dried over sodium sulfate and evaporated. The resulting solid was crystallized from ethanol to afford 5.74 g (17.66 mmol; 68%) of (3-amino-6-iodo-pyrazin-2-yl)-phenyl-methanone as yellow-orange crystals. 1H-NMR (d6-DMSO) δ: 8.52 [1H] s, 7.94 [2H] s, br, 7.85 [2H] d, 7.62 [1H] t, 7.52 [2H] t. MS: m/z 326 [MH+].
Aufarbeitung
- temperatureto warm to 10° C.
- customthe phases were separated
- extractionThe aqueous phase was extracted three times with dichloromethane
- dry with materialthe combined organic phases were dried over sodium sulfate
- customevaporated
- customThe resulting solid was crystallized from ethanol
Quellen und Nachweise
- ORD-Eintrag
- ord-230b8dfb2da3478383144da2ac9fef0e
- Quelldatensatz
- uspto-grants-2010_11
- Patentnummer
- US07829558B2
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