Ethyl Acetate → HCID 68772395, compound

HRID 1172344Notes

Reaction equation

HRID 1172344 reaction equation
O=C1C2C(=CC=CC=2)C(=O)[N:3]1[CH2:12][C:13]1[CH2:14][C@@H:15]([NH:28][C:29](=[O:35])[O:30][C:31]([CH3:34])([CH3:33])[CH3:32])[C@H:16]([C:19]2[CH:24]=[C:23]([F:25])[C:22]([F:26])=[CH:21][C:20]=2[F:27])[CH2:17][CH:18]=1.O.NN.C(OCC)(=O)C.[OH-].[Na+]>C(Cl)Cl.CO>[NH2:3][CH2:12][C:13]1[CH2:14][C@@H:15]([NH:28][C:29](=[O:35])[O:30][C:31]([CH3:33])([CH3:32])[CH3:34])[C@H:16]([C:19]2[CH:24]=[C:23]([F:25])[C:22]([F:26])=[CH:21][C:20]=2[F:27])[CH2:17][CH:18]=1

Participants

7

Reactant 4

HCID 8857Ethyl AcetateHCID 14798Sodium HydroxideHCID 24654Hydrazine hydrate (1:1)HCID 68771954HCID 68771954, compound

Product 1

HCID 68772395HCID 68772395, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of Example 58A (650 mg, 1.07 mmol) in 3 mL each of CH2Cl2 and methanol was treated with hydrazine hydrate (336 μL). Ethyl acetate and 1N NaOH were added. The organic phase was dried (Na2SO4) and concentrated in vacuo to give the title compound.

Workup

  1. dry with materialThe organic phase was dried (Na2SO4)
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-8b46b2ac29414460a416040d52182f63
Source dataset
uspto-grants-2010_11
Patent number
US07834012B2

Reaction notes

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