反应详情

温度

140 °C

4.24 g of potassium carbonate was added to N-methylpyrrolidone (4.24 mL) solution of 4.24 g of 2-fluoro-5-nitrobenzyl alcohol and 4.24 g of N-ethylpiperazine, and stirred at 140° C. for 14 hours. Water was added to the reaction liquid, and extracted with ethyl acetate. The organic layer was washed with water and saturated saline water in that order, then dried with anhydrous magnesium sulfate, and the solvent was evaporated away under reduced pressure. The crude product was purified through silica gel column chromatography (hexane/ethyl acetate) to obtain the entitled compound as a yellow solid.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water and saturated saline water in that order
3. dry with materialdried with anhydrous magnesium sulfate
4. customthe solvent was evaporated away under reduced pressure
5. customThe crude product was purified through silica gel column chromatography (hexane/ethyl acetate)