Chlorosuccinimide → HCID 68689537, compound

HRID 1172791Notes

Reaction equation

HRID 1172791 reaction equation
FC(F)(F)C([O-])=O.FC1C=CC(CC2N3C=C(C)C=C3C(=O)NC=2)=CC=1C(N1CCC[NH2+]CC1)=O.[F:36][C:37]1[CH:45]=[CH:44][C:43]([CH2:46][C:47]2[N:52]3[CH:53]=[C:54]([CH3:56])[CH:55]=[C:51]3[C:50](=[O:57])[NH:49][CH:48]=2)=[CH:42][C:38]=1[C:39]([OH:41])=[O:40].[Cl:58]N1C(=O)CCC1=O>C1COCC1>[Cl:58][C:53]1[N:52]2[C:47]([CH2:46][C:43]3[CH:44]=[CH:45][C:37]([F:36])=[C:38]([CH:42]=3)[C:39]([OH:41])=[O:40])=[CH:48][NH:49][C:50](=[O:57])[C:51]2=[CH:55][C:54]=1[CH3:56]

Participants

5

Reactant 3

HCID 31398ChlorosuccinimideHCID 68688070HCID 68688070, compoundHCID 68692013HCID 68692013, compound

Product 1

HCID 68689537HCID 68689537, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of Example 4, D6 (1 eq) and N-chlorosuccinimide (2 eq) in THF was stirred at RT. The solvent was removed under reduced pressure and the resulting crude was used as such in the next step without purification. MS (ES) C16H12ClFN2O3 requires: 334, found: 335 (M+H)+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customwithout purification

Sources & evidence

ORD record
ord-fbbb5a1d62694ae18fe0d3ca31d8f3e2
Source dataset
uspto-grants-2010_11
Patent number
US07834015B2

Reaction notes

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