Cesium carbonate → HCID 68694432, compound

HRID 1172837Notes

Reaction equation

HRID 1172837 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10]([C:13]2[C:14]([CH2:27][CH2:28][CH3:29])=[N:15][CH:16]=[CH:17][C:18]=2[O:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)=[N:11][OH:12])=[C:4](F)[C:3]=1[Si](C)(C)C.C(=O)([O-])[O-].[Cs+].[Cs+]>CN(C=O)C.C(OCC)(=O)C>[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]2[C:10]([C:13]3[C:14]([CH2:27][CH2:28][CH3:29])=[N:15][CH:16]=[CH:17][C:18]=3[O:19][C:20]3[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=3)=[N:11][O:12][C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 10796Cesium carbonateHCID 87541557HCID 87541557, compound

Product 1

HCID 68694432HCID 68694432, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of the oxime from Step 8 (12.0 g, 27 mmol) and cesium carbonate (17 g, 54 mmol) in DMF (200 mL) was stirred at 80° C. for 18 h. The reaction was diluted with ethyl acetate and washed with water. The crude product was purified by chromatography on silica gel to give the title product.

Workup

  1. washwashed with water
  2. customThe crude product was purified by chromatography on silica gel

Sources & evidence

ORD record
ord-27f46c53139d41ed8479ed3a82ec5e20
Source dataset
uspto-grants-2010_11
Patent number
US07834036B2

Reaction notes

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