Methylamine → HCID 59556067, compound

HRID 1173194Notes

Reaction equation

HRID 1173194 reaction equation
[OH:1][C:2]1([C:12]2[CH:20]=[CH:19][C:15]([C:16](O)=[O:17])=[CH:14][CH:13]=2)[CH2:11][CH2:10][C:5]2([O:9][CH2:8][CH2:7][O:6]2)[CH2:4][CH2:3]1.CN.[CH3:23][N:24]([P+](ON1N=NC2C=CC=CC1=2)(N(C)C)N(C)C)C.F[P-](F)(F)(F)(F)F.C(N(CC)CC)C>CN(C=O)C.C(OCC)(=O)C.CCCCCC>[OH:1][C:2]1([C:12]2[CH:20]=[CH:19][C:15]([C:16]([NH:24][CH3:23])=[O:17])=[CH:14][CH:13]=2)[CH2:11][CH2:10][C:5]2([O:9][CH2:8][CH2:7][O:6]2)[CH2:4][CH2:3]1

Participants

7

Reactant 4

HCID 6329MethylamineHCID 8471TriethylamineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 15023906HCID 15023906, compound

Product 1

HCID 59556067HCID 59556067, compoundYield 70.4%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 21226206Ethyl acetate hexaneSolvent

Procedure

4-(8-Hydroxy-1,4-dioxaspiro[4.5]dec-8-yl)benzoic acid (560 mg, 2 mmol), methylamine (1.2 mL, 2.0 M THF solution), BOP reagent (1.07 g, 2.4 mmol) and 0.8 mL (6 mmol) of triethylamine were dissolved in 15 mL of DMF at room temperature. The reaction mixture was stirred at r.t. overnight. Direct chromatography on silica gel (flash chromatography grade) with 50% ethyl acetate-hexane gave 410 mg (70%) of the desired product: 1H NMR (CDCl3) δ 7.76 (2 H, d, J=11.2 Hz), 7.56 (2 H, d, J=10.9 Hz), 5.01 (H, s), 3.90 (4 H, s), 3.37 (3 H, s), 2.80-2.75 (2 H, m), 2.60-2.45 (2 H, m), 1.95-1.90 (2 H, m), 1.63-1.52 (2 H, m); MS: 292 (M+1)+.

Sources & evidence

ORD record
ord-6d4205df8727496f9dfc37404309aa22
Source dataset
uspto-grants-2010_11
Patent number
US07834021B2

Reaction notes

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