Ethanol → HCID 13634376, compound

HRID 1173759Notes

Reaction equation

HRID 1173759 reaction equation
Cl[C@H:2]([C@H:7]([OH:11])[CH2:8][CH2:9][CH3:10])[C:3]([O:5][CH3:6])=[O:4].C(O)C.C(=O)([O-])[O-].[K+].[K+]>C(OC)(C)(C)C>[CH2:8]([C@H:7]1[O:11][C@@H:2]1[C:3]([O:5][CH3:6])=[O:4])[CH2:9][CH3:10]

Participants

5

Reactant 3

HCID 702EthanolHCID 11430Potassium CarbonateHCID 86639464HCID 86639464, compound

Product 1

HCID 13634376HCID 13634376, compoundYield 104%

Reagents, catalysts & solvents 1

HCID 15413tert-Butyl methyl etherSolvent

Conditions

Temperature
15 °C

Procedure

Methyl (2R,3R)-2-chloro-3-hydroxyhexanoate (0.9 g, 5 mmol), ethanol (10 ml) and potassium carbonate (2.1 g, 15 mmol) were mixed, and the mixture was stirred at 15° C. for 14 hours. Methyl tert-butyl ether (20 ml) was added. The mixture was washed with water (10 ml) three times. The organic layer was concentrated under reduced pressure to obtain the title compound (0.75 g, yield: 100%).

Workup

  1. washThe mixture was washed with water (10 ml) three times
  2. concentrationThe organic layer was concentrated under reduced pressure

Sources & evidence

ORD record
ord-e2528be4d63c4a6f950cd948d0ebfbd5
Source dataset
uspto-grants-2010_11
Patent number
US07834190B2

Reaction notes

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