Hydrochloric Acid → HCID 67420738, compound

HRID 1174146Notes

Reaction equation

HRID 1174146 reaction equation
[CH2:1]([C@H:8]([NH:41]C(=O)OC(C)(C)C)[C@@H:9]([OH:40])[CH2:10][C@@H:11]([NH:19][C:20](=[O:39])[C@@H:21]([N:26]1[CH2:30][CH2:29][N:28]([CH2:31][C:32]2[N:33]=[C:34]([CH3:37])[S:35][CH:36]=2)[C:27]1=[O:38])[C@@H:22]([CH3:25])[CH2:23][CH3:24])[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>C1COCC1>[NH2:41][C@@H:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C@@H:9]([OH:40])[CH2:10][C@@H:11]([NH:19][C:20](=[O:39])[C@@H:21]([N:26]1[CH2:30][CH2:29][N:28]([CH2:31][C:32]2[N:33]=[C:34]([CH3:37])[S:35][CH:36]=2)[C:27]1=[O:38])[C@@H:22]([CH3:25])[CH2:23][CH3:24])[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86726176HCID 86726176, compound

Product 1

HCID 67420738HCID 67420738, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

A solution containing the product from Example 11E (0.27 g, 0.4 mmol) in THF (4 mL) was treated with an HCl solution (0.70 mL, 4 N in dioxane), heated at 60° C. for 3 hours, cooled to 25° C., and concentrated to give the title compound as the hydrochloride salt.

Workup

  1. temperaturecooled to 25° C.
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-1989c68c3a5643f09b0197c534987df8
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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