Diethylamine → HCID 67407508, compound

HRID 1174343Notes

Reaction equation

HRID 1174343 reaction equation
[CH2:1]([C@H:8]([NH:45]C(=O)OCC1C2C=CC=CC=2C2C1=CC=CC=2)[C@@H:9]([OH:44])[CH2:10][C@@H:11]([NH:19][C:20](=[O:43])[C@@H:21]([N:26]1[CH2:30][CH2:29][N:28]([CH2:31][C:32]2[C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[N:35]=[CH:34][CH:33]=2)[C:27]1=[O:42])[C@@H:22]([CH3:25])[CH2:23][CH3:24])[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(NCC)C>CN(C=O)C>[NH2:45][C@@H:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[C@@H:9]([OH:44])[CH2:10][C@@H:11]([NH:19][C:20](=[O:43])[C@@H:21]([N:26]1[CH2:30][CH2:29][N:28]([CH2:31][C:32]2[C:41]3[C:36](=[CH:37][CH:38]=[CH:39][CH:40]=3)[N:35]=[CH:34][CH:33]=2)[C:27]1=[O:42])[C@@H:22]([CH3:25])[CH2:23][CH3:24])[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 86599580HCID 86599580, compound

Product 1

HCID 67407508HCID 67407508, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
25 °C

Procedure

A solution containing the product from Example 134A (0.122 g, 0.147 mmol) in DMF (6 mL) was treated with diethylamine (1.5 mL), stirred at 25° C. for 1 hour, and partitioned between ethyl acetate and water. The organic phase was washed with brine and dried over MgSO4, filtered and concentrated to give the title compounds.

Workup

  1. custompartitioned between ethyl acetate and water
  2. washThe organic phase was washed with brine
  3. dry with materialdried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-7712a878da9246fd9759d7d037c3b729
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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