Hydrochloric Acid → HCID 67409048, compound

HRID 1174387Notes

Reaction equation

HRID 1174387 reaction equation
[CH3:1][C@@H:2]([CH2:17][CH3:18])[C@H:3]([N:11]1[CH2:15][CH2:14][NH:13][C:12]1=[O:16])[C:4]([O:6]C(C)(C)C)=[O:5].Cl>O1CCCC1>[CH3:1][C@@H:2]([CH2:17][CH3:18])[C@H:3]([N:11]1[CH2:15][CH2:14][NH:13][C:12]1=[O:16])[C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67405859HCID 67405859, compound

Product 1

HCID 67409048HCID 67409048, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
60 °C

Procedure

To a solution containing the product from Example 161A (0.49 g, 1.91 mmol) in tetrahydrofuran (10.0 mL) was added aqueous HCl solution (5.0 mL, 4 N), and the mixture was stirred at 60° C. for 12 hours. The solvent was evaporated to give a white solid, which was used without further purification.

Workup

  1. customThe solvent was evaporated
  2. customto give a white solid, which
  3. customwas used without further purification

Sources & evidence

ORD record
ord-c5e5764b9c454f9ebcee80c5db1c4389
Source dataset
uspto-grants-2010_11
Patent number
US07834043B2

Reaction notes

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