Chlorodifluoromethane → HCID 66746357, compound

HRID 1175758Notes

Reaction equation

HRID 1175758 reaction equation
[OH:1][C:2]1[C:14]2[O:13][C:9]3([CH2:12][CH2:11][CH2:10]3)[CH2:8][C:7](=[O:15])[C:6]=2[CH:5]=[CH:4][CH:3]=1.Cl[CH:17]([F:19])[F:18].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[F:18][CH:17]([F:19])[O:1][C:2]1[C:14]2[O:13][C:9]3([CH2:10][CH2:11][CH2:12]3)[CH2:8][C:7](=[O:15])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6372ChlorodifluoromethaneHCID 11430Potassium CarbonateHCID 66746581HCID 66746581, compound

Product 1

HCID 66746357HCID 66746357, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared by difluoromethoxylation of 3,4-Dihydro-8-hydroxy-4-oxo-spiro[2H-1-benzopyran-2,1′-cyclobutane] using chlorodifluoromethane gas in the presence: of potassium carbonate in DMF at 30-80° C.

Workup

  1. customat 30-80° C.

Sources & evidence

ORD record
ord-67dda38ec58b469a92e11581c6359af4
Source dataset
uspto-grants-2010_11
Patent number
US07842703B2

Reaction notes

Loading…