反应详情

A stirred solution of 1,3-dicarbomethoxybicyclo[3.2.1]octane (8.26 g, 36.5 mmol) in tetrahydrofuran (50 mL) and isopropanol (16 mL) was treated with a solution of lithium hydroxide hydrate (4.20 g, 100 mmol) in water (50 mL), and the mixture was heated to 60°-70° C. for 2 h with stirring. The organic solvents were removed in vacuo, and the alkaline aqueous solution was cooled on an ice bath and acidified with concentrated hydrochloric acid (10 mL). The solid was filtered, rinsed with cold water, and partially air dried overnight, then further dried under vacuum, triturated from acetonitrile, and redried in vacuo to afford 6.25 g (86%) of subject material as a white solid. No MS could be obtained. 1H NMR (CDCl3+drop d6-DMSO) δ 2.15-2.25 (m, 1H), 1.95-2.05 (m, 2H), 1.40-1.70 (m, 9H).

1. temperaturethe mixture was heated to 60°-70° C. for 2 h
2. customThe organic solvents were removed in vacuo
3. temperaturethe alkaline aqueous solution was cooled on an ice bath
4. filtrationThe solid was filtered
5. washrinsed with cold water, and partially air
6. customdried overnight
7. customfurther dried under vacuum
8. customtriturated from acetonitrile
9. customredried in vacuo