Cyanuric chloride → HCID 178478357, compound

HRID 1176046Notes

Reaction equation

HRID 1176046 reaction equation
[CH:1]1([C:4]2[CH:5]=[C:6]([NH2:9])[NH:7][N:8]=2)[CH2:3][CH2:2]1.[Cl:10][C:11]1[N:16]=[C:15](Cl)[N:14]=[C:13]([Cl:18])[N:12]=1>C1COCC1>[CH:1]1([C:4]2[CH:5]=[C:6]([NH:9][C:15]3[N:14]=[C:13]([Cl:18])[N:12]=[C:11]([Cl:10])[N:16]=3)[NH:7][N:8]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 7954Cyanuric chlorideHCID 178507266HCID 178507266, compound

Product 1

HCID 178478357HCID 178478357, compoundYield 50.4%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

A solution of 5-Cyclopropyl-2H-pyrazol-3-ylamine (334 mg, 2.71 mmol) in 2 ml of THF was added dropwise to a solution of 2,4,6-Trichloro-[1,3,5]triazine (500 mg, 2.71 mmol) in 5 ml of THF at room temperature. After 1 hour, the precipitate was collected to afford 370 mg (50.4% yield) of the desired product.

Workup

  1. customthe precipitate was collected

Sources & evidence

ORD record
ord-f064491415da43cb924994cf14229aac
Source dataset
uspto-grants-2010_11
Patent number
US07842712B2

Reaction notes

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