4-Nitrobenzaldehyde → HCID 58751679, compound

HRID 1176192Notes

Reaction equation

C([O-])(=O)C.[NH4+:5].[C:6]([CH2:8][C:9]([O:11]C)=O)#[N:7].[CH3:13][CH:14]([CH3:18])[C:15](=O)[CH3:16].[N+:19]([C:22]1[CH:29]=[CH:28][C:25]([CH:26]=O)=[CH:24][CH:23]=1)([O-:21])=[O:20]>>[CH:14]([C:15]1[NH:5][C:9](=[O:11])[C:8]([C:6]#[N:7])=[C:26]([C:25]2[CH:28]=[CH:29][C:22]([N+:19]([O-:21])=[O:20])=[CH:23][CH:24]=2)[CH:16]=1)([CH3:18])[CH3:13]

Participants

Reactant 4

HCID 5414-Nitrobenzaldehyde

HCID 7747Methyl cyanoacetate

HCID 112513-Methyl-2-butanone

HCID 517165Ammonium Acetate

Product 1

HCID 58751679HCID 58751679, compound

Procedure

In analogy to the procedure described for Example 3a, reaction of 61.7 g ammonium acetate, 10.67 mL methyl cyanoacetate, 10.71 mL 3-methyl-butan-2-one, and 15.12 g 4-nitrobenzaldehyde yielded 4.24 g product.

Sources & evidence

ORD record: ord-71f1d80c6b3d4a3a925243d966233749
Source dataset: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07842809B2

Reaction notes

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