1-Hydroxybenzotriazole → HCID 25164724, compound

HRID 1177966Notes

Reaction equation

HRID 1177966 reaction equation
CCN(C(C)C)C(C)C.OC(C(F)(F)F)=O.[NH2:17][CH2:18][C:19]([N:21]1[CH2:26][CH2:25][N:24]([C:27](=[O:38])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[C:34]([F:37])([F:36])[F:35])[CH2:23][CH2:22]1)=[O:20].C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.Cl.[C:61]1([C:67]2[CH:75]=[CH:74][C:70]([C:71](O)=[O:72])=[CH:69][N:68]=2)[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=1>CN(C=O)C.O>[O:20]=[C:19]([N:21]1[CH2:22][CH2:23][N:24]([C:27](=[O:38])[C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[C:34]([F:37])([F:35])[F:36])[CH2:25][CH2:26]1)[CH2:18][NH:17][C:71](=[O:72])[C:70]1[CH:74]=[CH:75][C:67]([C:61]2[CH:66]=[CH:65][CH:64]=[CH:63][CH:62]=2)=[N:68][CH:69]=1

Participants

8

Reactant 5

HCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 1201186-Phenylnicotinic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 866340882-amino-1-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethanone TFA salt

Product 1

HCID 25164724HCID 25164724, compoundYield 70.7%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

DIPEA (77 mg, 0.6 mmol) was added to a stirred solution of 2-amino-1-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethanone TFA salt (103 mg, 0.24 mmol) in DMF (1 mL). HOBT (33 mg, 0.24 mmol) and EDCI.HCl (46 mg, 0.24 mmol) were then added at room temperature. After 2 minutes, 6-phenyl nicotinic acid (40 mg, 0.2 mmol) was added and the resulting mixture was stirred at room temperature for 4 hrs. Cold water was then added and the product was extracted with EtOAc and the organic layer was washed with brine. The organic phase was dried over Na2SO4 and concentrated under reduced pressure to afford 70 mg (70.7% yield) of N-{2-Oxo-2-[4-(2-trifluoromethyl-benzoyl)-piperazin-1-yl]-ethyl}-6-phenyl-nicotinamide. LCMS Purity: 92.6%, 1H NMR (DMSO-d6): δ 9.1 (s, 1H), 8.7 (t, 1H), 8.3 (d, 1H), 8.2-8.1 (m, 3H), 7.9-7.7 (m, 3H), 7.7-7.6 (m, 1H), 7.6-7.4 (m, 4H), 4.2 (m, 2H), 3.4-3.2 (m, 8H).

Workup

  1. extractionthe product was extracted with EtOAc
  2. washthe organic layer was washed with brine
  3. dry with materialThe organic phase was dried over Na2SO4
  4. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-9687cdac11544f13a281abacccff2a5a
Source dataset
uspto-grants-2010_11
Patent number
US07842696B2

Reaction notes

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