1-Methylpiperazine → HCID 69517728, compound

HRID 1179883Notes

Reaction equation

HRID 1179883 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:3].[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1.[K+].[Br-]>O>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][C:2]([N:16]2[CH2:17][CH2:18][N:13]([CH3:12])[CH2:14][CH2:15]2)=[O:3])=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 531671-MethylpiperazineHCID 1390594-Chlorophenyl chloroformateHCID 253877Potassium Bromide

Product 1

HCID 69517728HCID 69517728, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The hydrochloride of the title compound was prepared from 4-chlorophenyl chloroformate and 1-methylpiperazine, yield 81%. White crystals, m.p. 237-240° C.; 1H NMR (DMSO-d6): δ11.67 (br s, 1H), 7.50, 7.45, 7.24, 7.20 (AB-system, d=7.47 and 7.22; J=8.84 Hz, 4H), 4.40-3.91 (br, 2H, 3.77-2.92 (br m, 6H+water), 2.77 (s, 3H); IR (KBr): ν 1717 (C═O) cm −1.

Sources & evidence

ORD record
ord-07b2414d8e6841488f5e4ddf83d49a21
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Reaction notes

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