2-Bromopyridine → (4-Bromophenyl)(pyridin-2-yl)methanol

HRID 1180390Notes

Reaction equation

HRID 1180390 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[Br:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[O:14])=[CH:11][CH:10]=1>>[Br:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=2)[OH:14])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 79732-BromopyridineHCID 707414-Bromobenzaldehyde

Product 1

HCID 12177878(4-Bromophenyl)(pyridin-2-yl)methanol

Procedure

Using the same protocol as described in example 22, step 1, 2-bromopyridine (477 μL, 5.0 mmol) was added to 4-bromobenzaldehyde (1.018 g, 5.5 mmol). The crude residue obtained was chromatographed on silica gel using 50% ethyl acetate in hexanes to afford the title compound.

Workup

  1. customThe crude residue obtained
  2. customwas chromatographed on silica gel using 50% ethyl acetate in hexanes

Sources & evidence

ORD record
ord-50a55c57eb3f493799c4498219d8cbd3
Source dataset
uspto-grants-2007_10
Patent number
US07279478B2

Reaction notes

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