3-Bromopyridine → (4-Bromophenyl)(pyridin-3-yl)methanol

HRID 1180394Notes

Reaction equation

HRID 1180394 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=1.[Br:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=[O:14])=[CH:11][CH:10]=1>>[Br:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][CH:7]=2)[OH:14])=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 122863-BromopyridineHCID 707414-Bromobenzaldehyde

Product 1

HCID 13282976(4-Bromophenyl)(pyridin-3-yl)methanol

Procedure

Using the same protocol as described in example 22, step 1, 3-bromopyridine (482 μL, 5.0 mmol) was added to 4-bromobenzaldehyde (1.018 g, 5.5 mmol). The crude residue was chromatographed on silica gel using 1% NH4OH and 9% MeOH in dichloromethane to afford the title compound.

Workup

  1. customThe crude residue was chromatographed on silica gel using 1% NH4OH and 9% MeOH in dichloromethane

Sources & evidence

ORD record
ord-b7547f18c75e4ae98d84d5b629f8a184
Source dataset
uspto-grants-2007_10
Patent number
US07279478B2

Reaction notes

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