反应详情

温度

-20 °C

N-[2-(1-Benzhydryl-5-chloro-1H-indol-2-yl)-ethyl]-C-(2,6-dimethyl-phenyl)-methanesulfonamide (300 g, 552 mmol), 4-(3-Oxo-propyl)-benzoic acid ethyl ester (250 g, 1.21 mol), triethylsilane (192 g, 1.66 mol), and dichloromethane (2.9 L) were combined, stirred, and cooled to −20° C. A solution of boron trifluoride etherate (55.0 g, 322 mmol) in dichloromethane (10 mL) was added to the reaction mixture over 9 min. After 35 min, trifluoroacetic acid (63 g, 553 mmol) was added to the reaction mixture. After 40 min, the reaction mixture was filtered cold through a celite pad into aqueous sodium bicarbonate (138 g/1.5 L). The organic layer was concentrated to 1.2 L g, then ethanol (1.5 L) was added. The solution was concentrated to 1.2 L. THF (450 mL) and a solution of aqueous sodium hydroxide (221 g, 2.76 mol) were added. The reaction mixture was then warmed to reflux for 30 min. The mixture was cooled to 50° C. Toluene (1.5 L), water (300 mL) and acetic acid (166 g, 2.76 mol) were added. The organic and aqueous phases were separated and the organic phase was concentrated to 1.2 L. Toluene (600 mL) was added and the mixture was concentrated to 1.2 L. The mixture was cooled to room temperature and stirred for 16 h. The solid was collected by filtration, washed with cold toluene (3×300 mL), and dried to give 317 g (81%) of the title compound.

1. waitAfter 40 min
2. filtrationthe reaction mixture was filtered cold through a celite pad into aqueous sodium bicarbonate (138 g/1.5 L)
3. concentrationThe organic layer was concentrated to 1.2 L g
4. additionethanol (1.5 L) was added
5. concentrationThe solution was concentrated to 1.2 L
6. temperatureThe reaction mixture was then warmed
7. temperatureto reflux for 30 min
8. temperatureThe mixture was cooled to 50° C
9. customThe organic and aqueous phases were separated
10. concentrationthe organic phase was concentrated to 1.2 L
11. additionToluene (600 mL) was added
12. concentrationthe mixture was concentrated to 1.2 L
13. temperatureThe mixture was cooled to room temperature
14. stirringstirred for 16 h
15. filtrationThe solid was collected by filtration
16. washwashed with cold toluene (3×300 mL)
17. customdried