反应详情

温度

90 °C

3-Iodo-2-methylpropane (4.6 g) and potassium carbonate (8.62 g) were added to a solution of 6-Chloro-3-methylpyrimidine-2,4[1H,3H]-dione (2.0 g) in dimethylformamide (10 ml). The mixture was heated at 90° C. for 18 hours then cooled to room temperature. The solution was diluted with 5% aqueous HCl solution until solution becomes acidic and extracted twice with diethyl ether. The combined organic extracts were dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified by column chromatography over silica eluting with hexanes: ethyl acetate (1:1) to give the subtitle compound (1.5 g).

1. temperaturethen cooled to room temperature
2. extractionextracted twice with diethyl ether
3. dry with materialThe combined organic extracts were dried over anhydrous sodium sulfate
4. filtrationfiltered
5. customevaporated under reduced pressure
6. customThe residue was purified by column chromatography over silica eluting with hexanes: ethyl acetate (1:1)