反应详情

6 g (29.12 mmol) of methyl 2,6-dichloropyridine-3-carboxylate, 5.56 g (29.12 mmol) of 2,4-dichlorophenylboronic acid, 12.07 g (87.4 mmol) of potassium carbonate and then 1.68 g (1.46 mmol) of tetrakis(triphenylphosphine)palladium(0) were initially charged in 120 ml of degassed THF, and the mixture was heated under reflux conditions and under an argon atmosphere for 16 h. 300 ml of water and 500 ml of ethyl acetate were added. After separating the phases and removing the solvent, the residue was chromatographed on silica gel (cyclohexane/ethyl acetate 6:1). 2.5 g (27% of theory) of the product were isolated in solid form.

1. temperaturethe mixture was heated under reflux conditions and under an argon atmosphere for 16 h
2. customAfter separating the phases
3. customremoving the solvent
4. customthe residue was chromatographed on silica gel (cyclohexane/ethyl acetate 6:1)
5. custom2.5 g (27% of theory) of the product were isolated in solid form