Hydroxylamine → HCID 53327292, compound

HRID 1183112Notes

Reaction equation

HRID 1183112 reaction equation
[NH2:1][OH:2].[F:3][C:4]1[CH:22]=[CH:21][C:7]([CH2:8][C:9]2[C:10]([CH3:20])=[C:11]([OH:19])[C:12]([C:15](OC)=[O:16])=[N:13][CH:14]=2)=[CH:6][CH:5]=1>O1CCCC1>[F:3][C:4]1[CH:22]=[CH:21][C:7]([CH2:8][C:9]2[C:10]([CH3:20])=[C:11]([OH:19])[C:12]([C:15]([NH:1][OH:2])=[O:16])=[N:13][CH:14]=2)=[CH:6][CH:5]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 67294292HCID 67294292, compound

Product 1

HCID 53327292HCID 53327292, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5.0 mL of hydroxylamine solution (50 wt. % in water) was added to a solution of 0.169 g of methyl 5-(4-fluorobenzyl)-3-hydroxy-4-methylpicolinate 7c (0.615 mmol, 1 eq) in 5.0 mL of tetrahydrofuran. The reaction mixture was stirred at reflux overnight.

Workup

  1. temperatureat reflux overnight

Sources & evidence

ORD record
ord-852508cd7a8a4e1d99f9eafc8ade5636
Source dataset
uspto-grants-2014_03
Patent number
US08664248B2

Reaction notes

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