反应详情

To a solution of 0.865 g 5-(4-chloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-pyridazine-3-carboxylic acid methyl ester in 9.0 ml tetrahydrofurane was added 3.2 ml of a 1M of lithium hydroxide in water was added and the mixture was stirred at ambient temperature for 3 h. The reaction mixture was acidified with 1 M hydrochloric acid. The solid was collected by filtration washed with water and dried under high vacuum to yield 0.805 g of the title compound as white solid, MS (EI): 331.1 (M−H).

1. additionwas added
2. filtrationThe solid was collected by filtration
3. washwashed with water
4. customdried under high vacuum