Methanol → 5-Cyano-furan-2-carboxylic acid [2'fluoro-5-(4-methyl-piperazin-1-yl)-biphenyl-2-yl]-amide
Reaction equation
[C:24](#[N:25])[c:26]1[cH:27][cH:28][c:29]([C:31](=[O:32])[OH:33])[o:30]1.[CH3:49][OH:50].[CH:40]([N:41]([CH2:42][CH3:43])[CH:44]([CH3:45])[CH3:46])([CH3:47])[CH3:48].[Cl:34][C:35]([C:36]([Cl:37])=[O:38])=[O:39].[Cl:51][CH2:52][Cl:53].[F:1][c:2]1[c:3](-[c:8]2[cH:9][c:10]([N:17]3[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]3)[cH:11][cH:12][c:13]2[N+:14]([O-:15])=[O:16])[cH:4][cH:5][cH:6][cH:7]1.[O:54]=[CH:55][N:56]([CH3:57])[CH3:58]>>[F:1][c:2]1[c:3](-[c:8]2[cH:9][c:10]([N:17]3[CH2:18][CH2:19][N:20]([CH3:23])[CH2:21][CH2:22]3)[cH:11][cH:12][c:13]2[NH:14][C:31]([c:29]2[cH:28][cH:27][c:26]([C:24]#[N:25])[o:30]2)=[O:32])[cH:4][cH:5][cH:6][cH:7]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-f7b40ff34d104b99a97639b957bd6ea4
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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