2-Methoxyethylamine → HCID 17834439, compound
Reaction equation
[CH3:1][O:2][CH2:3][CH2:4][NH2:5].[S:6](N)([NH2:9])(=[O:8])=[O:7]>O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][NH:5][S:6](=[O:8])(=[O:7])[NH2:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
According to Reference Example 9-26, tetrahydrofuran (3 mL) and 2-methoxyethylamine (0.36 mL, 4.2 mmol) were added to sulfamide (400 mg, 4.2 mmol) and the mixture was stirred by use of a microwave chemical reactor at 300 W at 100° C. for 10 minutes. The solvent was evaporated off under reduced pressure, and purification by silica gel column chromatography (hexane/ethyl acetate=1/0 to 1/4) was performed to give N-(2-methoxyethyl)sulfuric diamide (Compound GF) (236 mg, yield: 37%).
Workup
- customThe solvent was evaporated off under reduced pressure, and purification by silica gel column chromatography (hexane/ethyl acetate=1/0 to 1/4)
Sources & evidence
- ORD record
- ord-96ef415c208c48ffaec8001bca104360
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08673908B2
Reaction notes
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