Chloride → N-tert.-butyl-6-chloro-4-(prop-2-yl)-nicotinamide

HRID 118743Notes

Reaction equation

HRID 118743 reaction equation
[C:6]([CH3:7])([CH3:8])([CH3:9])[NH:10][C:11]([c:12]1[cH:13][n:14][c:15]([Cl:18])[cH:16][cH:17]1)=[O:19].[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:20][OH:21].[CH:2]([CH3:3])([CH3:4])[Mg+:5].[Cl-:1].[Cl:22][C:23]1=[C:34]([Cl:35])[C:32](=[O:33])[C:29]([C:30]#[N:31])=[C:26]([C:27]#[N:28])[C:24]1=[O:25]>>[CH:2]([CH3:3])([CH3:4])[c:17]1[c:12]([C:11]([NH:10][C:6]([CH3:7])([CH3:8])[CH3:9])=[O:19])[cH:13][n:14][c:15]([Cl:18])[cH:16]1

Participants

7

Reactant 6

HCID 312ChlorideHCID 887MethanolHCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 8028TetrahydrofuranHCID 11816697N-tert-butyl-6-chloronicotinamideHCID 178461726HCID 178461726, compound

Product 1

HCID 11414149N-tert.-butyl-6-chloro-4-(prop-2-yl)-nicotinamide

Sources & evidence

ORD record
ord-2ead34a70fa64e1087e236eaeea502f2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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