反应详情

To the solution of 4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine (1.0 g, 5.97 mmol, 1.0 eq) and (S)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate (1.32 g, 6.57 mmol, 1.1 eq) and PPh3 (3.03 g, 11.94 mmol, 2.0 eq) in THF (50 mL), DIEA (2.08 g, 11.94 mmol, 2.0 eq) was added at 0° C. The resulted mixture was stirred and warmed to RT for 12 h. Solvent was removed and purified by column chromatography (eluting with 10% EtOAc in PE) to afford (S)-tert-butyl 2-[(4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl]methyl)pyrrolidine-1-carboxylate as a white solid (2.08 g, 100% in yield).

1. customSolvent was removed
2. custompurified by column chromatography (eluting with 10% EtOAc in PE)
3. customto afford