Hydrochloric Acid → HCID 86643472, compound

HRID 1188111Notes

Reaction equation

HRID 1188111 reaction equation
[CH2:1]([NH:8][C:9]1[S:10][C:11]([CH2:14][NH:15][C:16]2[CH:20]=[C:19]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=3)[NH:18][N:17]=2)=[CH:12][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CCOC(C)=O.[ClH:34]>>[ClH:34].[ClH:34].[CH2:1]([NH:8][C:9]1[S:10][C:11]([CH2:14][NH:15][C:16]2[CH:20]=[C:19]([C:21]3[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=3)[NH:18][N:17]=2)=[CH:12][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 25001105HCID 25001105, compound

Product 1

HCID 86643472HCID 86643472, compoundYield 25%

Procedure

N-Benzyl-5-((5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)methyl)thiazol-2-amine (59 mg, 0.13 mmol) was dissolved in methanolic HCl (3 N, 1 mL) and AcOEt was added. The precipitated solid was filtered by decantation and dried in vacuo, yielding N-benzyl-5-((5-(4-fluorophenyl)-1H-pyrazol-3-ylamino)methyl)thiazol-2-amine dihydrochloride as a yellow solid (14 mg, 25%).

Workup

  1. filtrationThe precipitated solid was filtered by decantation
  2. customdried in vacuo

Sources & evidence

ORD record
ord-4efea87b4bac45138a582a51a855ef42
Source dataset
uspto-grants-2014_03
Patent number
US08673940B2

Reaction notes

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