反应详情

温度

50 °C

A mixture of 7-methoxy-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indole-2-carboxylic acid (0.9 g), N-ethyl-N′-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.95 g), 1-hydroxybenzotriazole (0.67 g) and N,N-dimethylformamide (15 mL) was stirred at 50° C. for 20 min. The mixture was cooled to room temperature, and 10% aqueous ammonium hydroxide solution (2 mL) was added to the mixture. After stirring at room temperature for 2 h, the mixture was concentrated under reduced pressure. Water was added to the residue and the resulting yellow suspension was filtered to give the title compound (0.66 g, 74%) as a yellow solid. MS 362 (MH+).

1. temperatureThe mixture was cooled to room temperature
2. stirringAfter stirring at room temperature for 2 h
3. concentrationthe mixture was concentrated under reduced pressure
4. additionWater was added to the residue
5. filtrationthe resulting yellow suspension was filtered