2-Chlorophenol → 2-Chlorophenyl pent-4-ynoate

HRID 1189326Notes

Reaction equation

HRID 1189326 reaction equation
[C:1]([OH:7])(=[O:6])[CH2:2][CH2:3][C:4]#[CH:5].[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1O>>[C:1]([O:7][C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[Cl:8])(=[O:6])[CH2:2][CH2:3][C:4]#[CH:5]

Participants

3

Reactant 2

HCID 72452-ChlorophenolHCID 224644-Pentynoic acid

Product 1

HCID 860868272-Chlorophenyl pent-4-ynoateYield 87.1%

Procedure

According to the protocol described in Example 235(B), the reaction between pent-4-ynoic acid (590 mg, 6.0 mmol) and 2-chlorophenol (771 mg, 6.0 mmol) afforded 1.09 g of 2-chlorophenyl pent-4-ynoate (Yield: 87%) as colorless-oil.

Sources & evidence

ORD record
ord-7422e562b1b242879afbe881c4dcbf6c
Source dataset
uspto-grants-2014_03
Patent number
US08674106B2

Reaction notes

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