Hydrochloric Acid → HCID 178482236, compound

HRID 1189643Notes

Reaction equation

HRID 1189643 reaction equation
[F:1][C:2]([F:25])([F:24])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:23])[C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([NH:20][CH3:21])=[CH:13][C:12]=2Cl)[CH2:5][CH2:4]1.[F:26][C:27]1([F:32])[CH2:31][CH2:30][NH:29][CH2:28]1.Cl.CCN(C(C)C)C(C)C>O1CCOCC1>[F:1][C:2]([F:25])([F:24])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:23])[C:11]2[CH:16]=[C:15]([N+:17]([O-:19])=[O:18])[C:14]([NH:20][CH3:21])=[CH:13][C:12]=2[N:29]2[CH2:30][CH2:31][C:27]([F:32])([F:26])[CH2:28]2)[CH2:5][CH2:4]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 27828273,3-DifluoropyrrolidineHCID 178482185HCID 178482185, compound

Product 1

HCID 178482236HCID 178482236, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The sub-title compound is prepared in analogy to procedure 6a from N-(trans-4-trifluoromethyl-cyclohexyl)-2-chloro-4-methylamino-5-nitro-benzoic acid amide (190 mg, 0.50 mmol), 3,3-difluoro-pyrrolidine×HCl (143 mg, 1.00 mmol), DIPEA (0.34 mL, 2.0 mmol) and dioxane (10 mL).

Sources & evidence

ORD record
ord-3c556be93e294845afa9f33d3eab9c29
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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