Hydrochloric Acid → HCID 67957189, compound

HRID 1189686Notes

Reaction equation

HRID 1189686 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1Cl.[F:17][C:18]([F:26])([F:25])[CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.Cl.CCN(C(C)C)C(C)C>O1CCOCC1>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[N:22]1[CH2:23][CH2:24][CH:19]([C:18]([F:26])([F:25])[F:17])[CH2:20][CH2:21]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 81531DiisopropylethylamineHCID 1364694-(Trifluoromethyl)piperidineHCID 67957559Methyl 2-chloro-4-(methylamino)-5-nitrobenzoate

Product 1

HCID 67957189HCID 67957189, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The sub-title compound is prepared in analogy to 26a from methyl-2-chloro-4-methylamino-5-nitro-benzoate (1.37 g, 5.6 mmol), 4-trifluoromethylpiperidine×HCl (1.27 g, 6.7 mmol), DIPEA (3.8 mL, 22 mmol) and dioxane (50 mL).

Sources & evidence

ORD record
ord-2ab3acc197904a6a960bc18143170a8f
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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