Diisopropylcarbodiimide → HCID 86666491, compound

HRID 1189698Notes

Reaction equation

HRID 1189698 reaction equation
[F:1][C:2]([F:28])([F:27])[CH2:3][CH2:4][NH:5][C:6](=[O:26])[C:7]1[CH:12]=[C:11]([NH2:13])[C:10]([NH:14][CH3:15])=[CH:9][C:8]=1[N:16]1[CH2:21][CH2:20][CH:19]([C:22]([F:25])([F:24])[F:23])[CH2:18][CH2:17]1.[C:29]([O:33][C:34](=[O:48])[NH:35][CH2:36][C:37]1[CH:42]=[CH:41][C:40]([Cl:43])=[C:39]([N:44]=[C:45]=S)[C:38]=1[Cl:47])([CH3:32])([CH3:31])[CH3:30].CC(C)N=C=NC(C)C>CN(C=O)C>[F:28][C:2]([F:1])([F:27])[CH2:3][CH2:4][NH:5][C:6]([C:7]1[C:8]([N:16]2[CH2:21][CH2:20][CH:19]([C:22]([F:23])([F:24])[F:25])[CH2:18][CH2:17]2)=[CH:9][C:10]2[N:14]([CH3:15])[C:45]([NH:44][C:39]3[C:40]([Cl:43])=[CH:41][CH:42]=[C:37]([CH2:36][NH:35][C:34]([O:33][C:29]([CH3:32])([CH3:31])[CH3:30])=[O:48])[C:38]=3[Cl:47])=[N:13][C:11]=2[CH:12]=1)=[O:26]

Participants

5

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840196(2,4-Dichloro-3-isothiocyanato-benzyl)-carbamic acid tert-butyl ester2×HCID 86666490HCID 86666490, compound

Product 1

HCID 86666491HCID 86666491, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The title compound is prepared in analogy to 1e from N-(3,3,3-trifluoro-propyl)-2-[4-trifluoromethyl-piperidinyl]-4-methylamino-5-amino-benzoic acid amide (2.3 g, 5.6 mmol), (2,4-dichloro-3-isothiocyanato-benzyl)-carbamic acid tert.-butyl ester (compound B; 1.85 g, 5.6 mmol), DIC (1.0 mL) and DMF (10 mL).

Sources & evidence

ORD record
ord-cd06fe3f4f2b449aaa3d3aa04c5e0386
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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