Dimethylformamide → 2-(3-Bromo-5-chlorophenoxy)-3-chloro-6-fluorobenzaldehyde

HRID 118982Notes

Reaction equation

HRID 118982 reaction equation
[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH:18]([N-:19][CH:20]([CH3:21])[CH3:22])([CH3:23])[CH3:24].[Cl:1][c:2]1[c:3]([O:9][c:10]2[cH:11][c:12]([Br:17])[cH:13][c:14]([Cl:16])[cH:15]2)[cH:4][c:5]([F:8])[cH:6][cH:7]1.[Li+:25].[O:26]=[CH:27][N:28]([CH3:29])[CH3:30]>>[Cl:1][c:2]1[c:3]([O:9][c:10]2[cH:11][c:12]([Br:17])[cH:13][c:14]([Cl:16])[cH:15]2)[c:4]([CH:27]=[O:26])[c:5]([F:8])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 5062348DiisopropylamideHCID 568335523-Bromo-5-chlorophenyl 2-chloro-5-fluorophenyl ether

Product 1

HCID 568335532-(3-Bromo-5-chlorophenoxy)-3-chloro-6-fluorobenzaldehyde

Sources & evidence

ORD record
ord-f9e615a8e2754f52bdcbe0deb9aa8d83
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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