Pinacol → Anthracene

40.0 ml of n-BuLi (2.5M in hexane) are added to a suspension of 19.5 g (40 mmol) of 9,10-bis(2-bromophenyl)anthracene in 1000 ml of diethyl ether, and the mixture is stirred at room temperature for 6 h. The reaction mixture is subsequently cooled to −78° C., and 26.8 ml (240 mmol) of trimethyl borate are added rapidly with vigorous stirring. After slow warming to room temperature, a mixture of 8 ml of acetic acid and 300 ml of water and then 500 ml of ethyl acetate are added, the mixture is stirred at room temperature for a further 1 h, and the organic phase is separated off, washed twice with 500 ml of water and evaporated under reduced pressure. 300 ml of toluene and 10.6 g (90 mmol) of pinacol are added to the residue, and the mixture is heated on a water separator. When the separation of water is complete, 250 ml of toluene are distilled off, and 300 ml of ethanol are added. After cooling, the colourless solid is filtered off with suction, recrystallised three times from toluene and dried under reduced pressure. Sublimation, p=1×10−5 mbar, T=260° C. Yield: 10.6 g (18 mmol), 45.5% of theory; purity: 99.9% according to 1H-NMR.

1. temperatureThe reaction mixture is subsequently cooled to −78° C.
2. temperatureAfter slow warming to room temperature
3. stirringthe mixture is stirred at room temperature for a further 1 h
4. customthe organic phase is separated off
5. washwashed twice with 500 ml of water
6. customevaporated under reduced pressure
7. customWhen the separation of water
8. distillation250 ml of toluene are distilled off
9. addition300 ml of ethanol are added
10. temperatureAfter cooling
11. filtrationthe colourless solid is filtered off with suction
12. customrecrystallised three times from toluene
13. customdried under reduced pressure
14. customSublimation, p=1×10−5 mbar, T=260° C

ORD record

ord-39cb970267ac457daaf092981fe5d0aa

Source dataset

uspto-grants-2014_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08674141B2