Hydrochloric Acid → HCID 56651010, compound

HRID 1191311Notes

Reaction equation

HRID 1191311 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[C:13]4[CH:21]=[CH:20][CH:19]=[CH:18][C:14]4=[CH:15][CH:16]=3)[NH:11][C:10](=[O:22])[N:9]=2)[CH:5]=[CH:6][CH:7]=1.CO.[ClH:25]>C(Cl)(Cl)Cl.C(OCC)(=O)C>[ClH:25].[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[C:13]4[CH:21]=[CH:20][CH:19]=[CH:18][C:14]4=[CH:15][CH:16]=3)[NH:11][C:10](=[O:22])[N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 56651011HCID 56651011, compound

Product 1

HCID 56651010HCID 56651010, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 6212ChloroformSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 4-(3-aminophenyl)-1H-benzo[h]quinazolin-2-one (25 mg, 0.087 mmol) in chloroform (2 mL)/methanol (1 mL) was added a solution of 4M hydrogen chloride in ethyl acetate (1 mL), and stirred for 1 hour. The solvent was removed under reduced pressure to give the titled compound as a orange powder (30 mg, yield 100%).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-a805d2298899426bb3e41325669db506
Source dataset
uspto-grants-2014_03
Patent number
US08680110B2

Reaction notes

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