Sodium → HCID 21270775, compound

HRID 1193876Notes

Reaction equation

HRID 1193876 reaction equation
Cl[C:2]1[N:3]([C:16]2[CH:21]=[C:20]([O:22][CH:23]([CH3:25])[CH3:24])[C:19]([Cl:26])=[CH:18][C:17]=2[F:27])[C:4](=[O:15])[CH:5]=[C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])[N:7]=1.[Na]>C(O)(C)C>[Cl:26][C:19]1[C:20]([O:22][CH:23]([CH3:25])[CH3:24])=[CH:21][C:16]([N:3]2[C:4](=[O:15])[CH:5]=[C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])[N:7]=[C:2]2[O:22][CH:20]([CH3:21])[CH3:19])=[C:17]([F:27])[CH:18]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 21270720HCID 21270720, compound

Product 1

HCID 21270775HCID 21270775, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

using 2-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-pentafluoroethyl-6(1H)-pyrimidinone and sodium isopropylate in isopropanol there is obtained 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-isopropoxy-4-pentafluoroethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.30 ppm (d,1H), 6.81 ppm (d,1H), 6.62 ppm (s,1H), 5.33 ppm (m,1H), 4.47 ppm (m,1H), 1.38 ppm (d,3H), 1.37 ppm (d,3H), 1.28 ppm (d,3H), 1.27 ppm (d,3H);

Sources & evidence

ORD record
ord-ee4d471f7bb94329b88e0827b8e2be07
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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