Sodium → HCID 21270713, compound

HRID 1193878Notes

Reaction equation

HRID 1193878 reaction equation
Cl[C:2]1[N:3]([C:16]2[CH:21]=[C:20]([O:22][CH:23]([CH3:25])[CH3:24])[C:19]([Cl:26])=[CH:18][C:17]=2[F:27])[C:4](=[O:15])[CH:5]=[C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])[N:7]=1.[Na]>C(O)CC>[Cl:26][C:19]1[C:20]([O:22][CH:23]([CH3:25])[CH3:24])=[CH:21][C:16]([N:3]2[C:4](=[O:15])[CH:5]=[C:6]([C:8]([F:14])([F:13])[C:9]([F:12])([F:11])[F:10])[N:7]=[C:2]2[O:15][CH2:4][CH2:5][CH3:6])=[C:17]([F:27])[CH:18]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 21270720HCID 21270720, compound

Product 1

HCID 21270713HCID 21270713, compound

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

using 2-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-pentafluoroethyl-6(1H)-pyrimidinone and sodium propylate in n-propanol there is obtained 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4 -pentafluoroethyl-2-(n-propoxy)-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.31 ppm (d,1H), 6.82 ppm (d,1H), 6.63 ppm (s,1H), 4.46 ppm (m,1H), 4.36 ppm (m,2H), 1.66 ppm (m,2H), 1.38 ppm (d,3H), 1.37 ppm (d,3H), o.85 ppm (t,3H);

Sources & evidence

ORD record
ord-77efb9a5970646ff9b0da878c971d362
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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