Methyl iodide → HCID 21270788, compound

HRID 1193909Notes

Reaction equation

HRID 1193909 reaction equation
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]=[C:10]2[O:20][CH3:21])=[C:4]([F:22])[CH:3]=1.[CH3:23]I.[H-].[Na+]>CN(C)C=O>[Br:1][C:2]1[C:7]([O:8][CH3:23])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]=[C:10]2[O:20][CH3:21])=[C:4]([F:22])[CH:3]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 21270719HCID 21270719, compound

Product 1

HCID 21270788HCID 21270788, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using 1-(4-bromo-2-fluoro-5-hydroxyphenyl)-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone and methyl iodide with sodium hydride in dimethylformamide there is obtained 1-(4-bromo-2-fluoro-5-methoxyphenyl)-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 175°-177° C.;

Sources & evidence

ORD record
ord-cec2200ce3f24a73b05f779ecd8da850
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

Loading…