Allyl bromide → HCID 21270793, compound

HRID 1193910Notes

Reaction equation

HRID 1193910 reaction equation
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]=[C:10]2[O:20][CH3:21])=[C:4]([F:22])[CH:3]=1.[CH2:23](Br)[CH:24]=[CH2:25].[H-].[Na+]>CN(C)C=O>[CH2:25]([O:8][C:7]1[C:2]([Br:1])=[CH:3][C:4]([F:22])=[C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]=[C:10]2[O:20][CH3:21])[CH:6]=1)[CH:24]=[CH2:23]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 24758Sodium hydrideHCID 21270719HCID 21270719, compound

Product 1

HCID 21270793HCID 21270793, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using 1-(4-bromo-2-fluoro-5-hydroxyphenyl)-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone and allyl bromide with sodium hydride in dimethylformamide there is obtained 1-(5-allyloxy-4-bromo-2-fluorophenyl)-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone. m.p. 107°-110° C.;

Sources & evidence

ORD record
ord-96e3f09abea64ac986d9d30ef8740800
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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