Propargyl bromide → HCID 21270765, compound

HRID 1193911Notes

Reaction equation

HRID 1193911 reaction equation
[Br:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]=[C:10]2[O:20][CH3:21])=[C:4]([F:22])[CH:3]=1.[CH2:23](Br)[C:24]#[CH:25].[H-].[Na+]>CN(C)C=O>[Br:1][C:2]1[C:7]([O:8][CH2:25][C:24]#[CH:23])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:18])([F:17])[F:19])[N:11]=[C:10]2[O:20][CH3:21])=[C:4]([F:22])[CH:3]=1

Participants

5

Reactant 3

HCID 7842Propargyl bromideHCID 24758Sodium hydrideHCID 21270719HCID 21270719, compound

Product 1

HCID 21270765HCID 21270765, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using 1-(4-bromo-2-fluoro-5-hydroxyphenyl)-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone and propargyl bromide with sodium hydride in dimethylformamide there is obtained 1-[4-bromo-2-fluoro-5-(2-propynyloxy)-phenyl]-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 136°-138° C.

Sources & evidence

ORD record
ord-423b5a4873974e7abb38a4dbc6c76dec
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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