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HRID1193911

反应详情

EQUATION

反应方程式

HRID 1193911 的结构方程式

REACTANTS

反应物

3
结构：C#CCBr
HCID7842

Propargyl bromide

C3H3Br

结构：[H-].[Na+]
HCID24758

Sodium hydride

HNa

结构：COc1nc(C(F)(F)F)cc(=O)n1-c1cc(O)c(Br)cc1F
HCID21270719

未命名化合物

PRODUCTS

生成物

1
结构：C#CCOc1cc(-n2c(OC)nc(C(F)(F)F)cc2=O)c(F)cc1Br
HCID21270765

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

Dimethylformamide

C3H7NO

PROCEDURE

实验过程

using 1-(4-bromo-2-fluoro-5-hydroxyphenyl)-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone and propargyl bromide with sodium hydride in dimethylformamide there is obtained 1-[4-bromo-2-fluoro-5-(2-propynyloxy)-phenyl]-2-methoxy-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 136°-138° C.