Chloromethyl Methyl Ether → HCID 21270703, compound

HRID 1193913Notes

Reaction equation

HRID 1193913 reaction equation
[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[C:13]([F:16])=[C:12]([C:17]([F:23])([F:22])[C:18]([F:21])([F:20])[F:19])[N:11]=[C:10]2[O:24][CH3:25])=[C:4]([F:26])[CH:3]=1.[CH3:27][O:28][CH2:29]Cl.[H-].[Na+]>CN(C)C=O>[Cl:1][C:2]1[C:7]([O:8][CH2:27][O:28][CH3:29])=[CH:6][C:5]([N:9]2[C:14](=[O:15])[C:13]([F:16])=[C:12]([C:17]([F:22])([F:23])[C:18]([F:19])([F:21])[F:20])[N:11]=[C:10]2[O:24][CH3:25])=[C:4]([F:26])[CH:3]=1

Participants

5

Reactant 3

HCID 7864Chloromethyl Methyl EtherHCID 24758Sodium hydrideHCID 21270789HCID 21270789, compound

Product 1

HCID 21270703HCID 21270703, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

using 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-5-fluoro-2-methoxy-4-pentafluoroethyl-6(1H)-pyrimidinone and chlorodimethyl ether with sodium hydride in dimethylformamide there is obtained 1-(4-chloro-2-fluoro-5 -methoxymethoxy-phenyl)-5-fluoro-2-methoxy-4-pentafluoroethyl-6(1H)-pyrimidinone, 1H-NMR CDCl3, 400 MHz): 7.34 ppm (d,1H), 7.13 ppm (d,1H), 5.22 ppm (q,2H), 3.98 ppm (s,3H), 3.52 ppm (s,3H);

Sources & evidence

ORD record
ord-4d503760ad6040aa931f6f55e4e98b00
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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