Dimethylformamide → 2-Dimethylaminopyridine

HRID 1194047Notes

Reaction equation

HRID 1194047 reaction equation
[CH:1]1([N:7]=[C:8]=[N:9][CH:10]2[CH2:15][CH2:14][CH2:13]CC2)CCCCC1.[CH3:16]N(C)C=O>C(N(CC)CC)C.N1C=CC=CC=1>[CH3:16][N:7]([C:8]1[CH:13]=[CH:14][CH:15]=[CH:10][N:9]=1)[CH3:1]

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 10868Dicyclohexylcarbodiimide

Product 1

HCID 218852-Dimethylaminopyridine

Reagents, catalysts & solvents 2

HCID 8471TriethylamineCatalystHCID 1049PyridineSolvent

Procedure

This condensation is carried out in solution either in dimethylformamide using triethylamine as catalyst for 20 to 24 hours, or in pyridine in the presence of dicyclohexylcarbodiimide for one night to three days or in the presence of dimethylaminopyridine to obtain ##STR28##

Workup

  1. customfor 20 to 24 hours

Sources & evidence

ORD record
ord-5c112580e2254550a4c4f8214032cbe0
Source dataset
uspto-grants-1989_03
Patent number
US04812512

Reaction notes

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