Anisole → HCID 178503585, compound

HRID 1194297Notes

Reaction equation

HRID 1194297 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[CH:12][CH:13]=1)[N:7]=[C:8]([S:10][CH3:11])[N:9]=2.[C:14]1(OC)C=CC=CC=1.[F:22][C:23]([F:30])([F:29])[S:24]([O:27]C)(=[O:26])=[O:25]>C(OCC)(=O)C>[F:22][C:23]([F:30])([F:29])[S:24]([O-:27])(=[O:26])=[O:25].[CH3:14][N:9]1[C:5]2=[CH:4][CH:3]=[C:2]([CH3:1])[CH:13]=[CH:12][C:6]2=[NH+:7][CH:8]1[S:10][CH3:11]

Participants

5

Reactant 3

HCID 7519AnisoleHCID 9526Methyl triflateHCID 200643756-Methyl-2-(methylsulfanyl)cyclohepta[d]imidazole

Product 1

HCID 178503585HCID 178503585, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

6-Methyl-2-methylthiocycloheptimidazole (27 g) was added to 100 ml of anisole and stirred under ice cooling. Then, 28 g of methyl trifluoromethanesulfonate was added dropwise thereto, and stirred under ice cooling. The mixture was further stirred at room temperature for one hour, 200 ml of ethyl acetate was added, and deposited crystals were collected by filtration and dried.

Workup

  1. stirringstirred under ice cooling
  2. stirringThe mixture was further stirred at room temperature for one hour
  3. filtrationwere collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-75cb94b97c944c6da485b398bf71388d
Source dataset
uspto-grants-1989_03
Patent number
US04814265

Reaction notes

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