Isopropanol → HCID 15615520, compound

HRID 1194315Notes

Reaction equation

HRID 1194315 reaction equation
[NH:1]([C:8]1[N:13]=[C:12](Cl)[CH:11]=[C:10]([CH3:15])[N:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:16]([OH:19])([CH3:18])[CH3:17].[H-].[Na+]>C1COCC1>[NH:1]([C:8]1[N:9]=[C:10]([CH3:15])[CH:11]=[C:12]([O:19][CH:16]([CH3:18])[CH3:17])[N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 24758Sodium hydrideHCID 2492392-Anilino-4-chloro-6-methylpyrimidine

Product 1

HCID 15615520HCID 15615520, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In the same manner as in Example 3, 3.1 g of 2-anilino-4-chloro-6-methylpyrimidine, 1.9 g of isopropyl alcohol and 0.7 g of NaH were added to 50 ml of THF and allowed to react at room temperature for 4 hours to obtain 2.2 g of 2-anilino-4-methyl-6-isopropoxypyrimidine (yield 65%). nD20 1.5931.

Workup

  1. customto react at room temperature for 4 hours

Sources & evidence

ORD record
ord-9af46353338b41e280dcaa821c67d20f
Source dataset
uspto-grants-1989_03
Patent number
US04814338

Reaction notes

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