Dimethylformamide → HCID 70352844, compound

HRID 1194669Notes

Reaction equation

HRID 1194669 reaction equation
[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15](=O)[CH:16]([CH3:21])[CH2:17][C:18](O)=[O:19])=[C:11]([NH2:23])[C:10]=1[C:24]([NH2:26])=[O:25].O.[NH2:28][NH2:29].CN(C)C=O>C(O)C>[O:1]=[C:2]1[CH2:6][CH2:5][CH2:4][N:3]1[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:16]([CH3:21])[CH2:17][C:18](=[O:19])[NH:28][N:29]=2)=[C:11]([NH2:23])[C:10]=1[C:24]([NH2:26])=[O:25]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24654Hydrazine hydrate (1:1)HCID 70392765HCID 70392765, compound

Product 1

HCID 70352844HCID 70352844, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

7.2 g (0.02 mole) of 4-(4-(2-(2-oxo-pyrrolidin-1-yl)ethyl)-amino-carbonyl-amino-phenyl)-4-oxo-3-methyl-butyric acid and 1 ml (0.02 mole) of hydrazine hydrate are heated under reflux in 80 ml of ethanol and 10 ml of dimethylformamide for 2 hours. The crude product (6.3 g) which precipitates out on cooling is filtered off with suction and recrystallised from 90% strength ethanol.

Workup

  1. customThe crude product (6.3 g) which precipitates out
  2. temperatureon cooling
  3. filtrationis filtered off with suction
  4. customrecrystallised from 90% strength ethanol

Sources & evidence

ORD record
ord-3e334eec815844678aa096b9c01dd809
Source dataset
uspto-grants-1989_03
Patent number
US04816454

Reaction notes

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